Fermentation & Biocatalysis, Lonza Chemicals R&D, Lonza Ltd. Visp, Switzerland.
Dr Jürgen Riegler, PI
Lonza Ltd is one of the world’s leading suppliers to the pharmaceutical, healthcare and life science industries. Lonza is global leader in the production and support of active agrochemical, nutrition and pharmaceutical ingredients both chemically as well as biotechnologically. The group of Fermentation & Biocatalysis was established in the Department of Research and Development in Visp in 1983. This multi-disciplinary group encompasses the R&D and implementation of processes for large scale manufacture of chemicals for life sciences industries. A few examples of industrialized process from this group that have been carried out in multi Tonne scale are L-carnitine and nicotinamide, L-erythrulose, and 5-Hydroxy-2-pyrazine carboxylic acid.
Jürgen Riegler (PhD) joined Lonza in the position of Innovation Manager within Lonza Special Ingredients R&T department in January 2011. In this position he is responsible for managing internal and external innovation projects. As a specialty Jürgen is responsible for the Open Innovation activities of Lonza SI R&T. Therefore he manages academic collaborations and contacts especially the public funded research projects. Within this frame of responsibilities Jürgen is able to profit from his back engagements as vice group-leader for Nanomaterials at the Material Research Center of Freiburg, as Research Assistance Professor at Tohoku University in Sendai and as project- & group leader at Fraunhofer Institute for Interfacial- and Bio-engineering Stuttgart, respectively. Jürgen holds a PhD in Chemistry. Scientifically he did research in the field of nanomaterials and nanocrystals and their designed synthesis and functionalization for bioanalytical, diagnostic and electro-optical applications.
P4FIFTY project in Lonza Ltd, Visp.
Preparation of hydroxylated metabolites of industrial relevance in gram scale
Oxidative reactions are among the most important reactions increase functionality in organic molecules. Chemical methods are usually pursued because of their familiarity and the successful precedents in large scale. Selectivity of the catalyst and environmental impact on the wastewater are among the main problems. CYP450 oxidations have an exquisite selectivity and are becoming accessible for use in large scale. The stability of the catalyst becomes problematic especially during scale-up. The tasks envisioned for this project are the search of a suitable catalyst from a selected group if enzymes for the desired reaction, characterization of the catalyst and the investigation of the preferred redox partners. The advance of heterologous expression systems in combination with the use of different redox partners will allow overcoming this problem. Preparation of gram amounts of the desired product with new catalysts will demonstrate the utility and potential of these catalysts for industrial oxidations.